BACKGROUND Conventional fluorescent dyes used in nucleic acid detection methods suffer from a number of limitations. High backgrounds result in false positives and a reduction in sensitivity. The smal..
BACKGROUND Enzymes, especially proteases play essential roles in disease specific processes and are valuable targets for therapeutic intervention. A number of methods of targeting enzymes have been us..
BACKGROUND Pre-designed self-assembling scaffolds are highly advantageous in a number of areas, including tissue regeneration, 3D cell culture, in vitro toxicity testing and understanding of cell/extr..
BACKGROUND A research project in in the Faculty of Life Sciences at the University of Manchester has led to the development of a novel yeast-based drug delivery mechanism. THE TECHNOLOGY A genetically..
Background: Recently light-assisted activation of selected groups (expressing the same gene) of electrically excitable cells such as neurons has been made possible with high temporal precision by int..
Background: Currently seizures are detected from deep brain structures with the use of electroencephalography (EEG). EEG recordings are made through electrodes placed on the scalp, on the brain surfa..
Background: In biomedical research, controlled modulation of physiological functions of various excitable cells such as skeletal, cardiac and neuronal cells is important. The information derived from..
Background: Manipulation of microscopic objects by laser methods has been used since the 1970s. Both laser tweezers (used to hold microscopic objects in place) and optical scissors (used to conduct d..
Background: Use of instruments to assess etiology and status of chronic wounds is still in an embryonic state. Clinicians rely primarily on clinical features such as wound size, location, depth, and ..
Background: Cardiac catheterization is typically performed with stiff-tipped catheters. In order to engage a blood vessel orifice, the stiff tip must be positioned at a precise location, and in the c..
Background: Chemical cytometry involves the use of high-sensitivity analytical tools, such as mass spectrometry, electrochemistry and capillary or microfluidic separation methods to characterize sing..
Background: Type 2 Diabetes, also known as non-insulin dependent diabetes mellitus (NIDDM) or adult-onset diabetes is the most common form of diabetes affecting 90-95% of the 21 million Americans dia..
Background: Standard electrical motors when used in magnetic resonance (MR) instrumentation may interfere with the functionality of the MR imaging. These interferences from the motor distort the resu..
Background: In certain microfluidic devices, continuous mixing of fluids is desirable depending on the application.
For example, in the conventional or passive hybridization method, a DNA microarr..
Background: To date, cell lysis in microfluidic devices for analytical purposes has been achieved using chemical, electrical, and optical means. Chemical cell lysis occurs on time scales of several t..
Background: The means to regulate endotracheal tube cuff pressure have been proposed in order to decrease the incidence of post-intubation complications caused by cuffed endotracheal tube. The regula..
Background Scanning thermal microscopy is a high resolution scanning microscopy technique, which can map material topography, thermal conductivity and capacity, and temperature. As with other scanning..
Background: "Molecular Electronics" (ME) generally refers to a class of novel electronic devices in which the electronic response and function are entirely controlled by single molecules. In principl..
Background: The ability to deliver drugs locally to the site of need and over a prolonged period of time is important as a therapeutic method for many ailments and diseases. Many drugs are more effec..
Background: Laparoscopic surgery has become part of the standard armamentarium for many urologic surgeons. Currently a wide variety of instruments are used to facilitate dissection during laparoscopi..
Background: If blood is replaced locally in the vascular system by injection of saline solutions, OCT images can be obtained for brief periods of time, but lack of oxygen is deleterious to the tissue..
Background: Most of the current techniques used for Dielectrophoresis separation use planar electrodes which sit at the bottom of the channel. With this design the electric field decreases dramatical..
Background: Subsequent to a variety of medical procedures including, but not limited to knee arthroplasties, hip arthroplasties, and fracture repairs, post-operative weight-bearing on the affected le..
Background: Stem cells may hold the key to future cures for many diseases. These are embryonic cells that are thought to have the potential to develop in any kind of tissue: liver, kidney, brain, etc..
Background: In the chemical, biomedical, and pharmaceutical industries, it has become increasingly desirable to perform large numbers of chemical operations in a highly parallel fashion. For example,..
Background: In many neurodegenerative diseases and in spinal cord injury, axons and synapses are damaged; a cell culture model is useful for investigation into these areas of research. In typical cel..
Background: In dentistry there exists a pressing need for novel diagnostic modalities. A strong consensus for reducing patient exposure to ionizing radiation is countered by the absence of other non-..
Background: Ultrasound imaging may be used to produce a 2D image of the body's internal structures. However, since blood is much less (1000x less) echogenic than tissue, small vessels, blood pool vol..
Background: Breast cancer is a world wide public health concern and the estimated death toll in the U.S. in 2001 was 20,000 and it also ranked first as the cause of cancer death for women between the..
Background: In the past decade, droplets have been intensively used by the industries as an agent for drug preparations, for plastic polymerizations, and chemical processing. Recent advancements in m..
Background: A disadvantage of closed microfluidic channels are that they are made from different materials. Also, most of the microchannels are fabricated from lithography techniques which require th..
Background: Optical coherence tomography (OCT) has been used for high resolution optical imaging in many areas of medicine, especially ophthalmology. "Conventional wisdom" was that OCT could not be d..
Background: Today, most detection schemes for DNA, proteins and other large biomolecules involve luminescent measurements using a variety of labels (i.e. fluorescent and/or chemiluminescent probes, p..
Background: Conventional methods that create fluidic channels using photopolymers create channels and chambers by-coating, patterning, and developing each layer sequentially. These conventional metho..
Background: Cutaneous vascular lesions including port wine stains (PWS) and hemangiomas are frequently treated with laser and light devices. The pulsed dye laser (PDL) is the current standard means o..
Background: The ability to resist nonspecific protein adsorption (protein resistance) is an indicator of a material's biological inertness or biocompatibility. Protein resistant biomaterials such as ..
Background: A carbon nanotube (CNT) is a one-dimensional molecular wire which is believed to have many potential applications in upgrading the density and performance of electronic information system..
Background: One of the great limitations in spine surgery is the difficulty with removing bone without damaging adjacent soft structures (such as the spinal cord, nerves, and durra). This difficulty ..
Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady s..
Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady s..
Background: Ten percent of the general population suffers from hearing loss and that number rises to thirty five percent for people over sixty-five years of age. However, current digital hearing aids..
Background: Recent years have witnessed a significant interest in biological applications of novel solid-state nanomaterials. The unique physical properties of molecular or nanoscale solids when util..
A smart computer controlled bio-microfluidic probe station, which facilitates real-time non-invasive measurements of quantitative, cross sectional information of biological fluid flow at various locat..
Molecular imprinting is a process for synthesizing materials that contain highly specific recognition sites for smaller molecules. Today, molecular imprinting is used for many purposes, including the ..
Background: A complication of using a cryogen gas to provide cooling during laser irradiation of biological tissues is the formation of ice crystals. This formation of ice on the tissue surface cause..
Background Kidney disease is a major health problem in the United States, afflicting about 8 million Americans. Kidney disorders run the gamut from minor infections to total kidney failure. Many disea..
Background Cancer metastasis is a significant medical problem in the US, where it is estimated ~ 90% of cancer deaths in 2003 were a result of metastatic tumors. Several reports suggest a potential ro..
Background Kidney disease is a major health problem in the United States, afflicting about 8 million Americans. Kidney disorders run the gamut from minor infections to total kidney failure. Many disea..
Plasmid containing DNA sequences encoding erythorpoeitin receptor fused to the glutathione-S-transferase fusion protein. To be used to produce a glutathione-S-transferase/erythropoeitin receptor fusio..
Background Inflammatory Bowel Disease (IBD) is a group of gastrointestinal disorders, characterized by a chronic non-specific inflammation of portions of the gastrointestinal tract. Ulcerative colitis..
Background According to the American Cancer Society, prostate and breast cancer have the highest rate of new diagnosis in the US with approximately 200,000 new diagnoses for each every year. There is ..
Background Tissue engineering scaffolds may play a pivotal role in cell seeding, proliferation and new tissue formation in three dimensions. The structure and composition of the scaffold are critical ..
Background Image registration transforms different sets of data into a single coordinate system and is thus critical for comparison and integration of data obtained from different measurements. This t..
Background There are times when biologists need to search a large number of short DNA sequences. BLASTing a few sequences is not a problem since it can be easily done in NCBI's BLAST web servers or in..
The present invention provides methods and systems for running reactions, in particular, biological reactions and assays, in a Rayleigh-Bnard convection cell. The utilization of Rayleigh-Bnard convect..
APPLICATIONS OF TECHNOLOGY:
- Molecular biology research - Medical research
ABSTRACT: Telomeres are believed to be critical regulators of the genome, and telomere stability important for preventin..
APPLICATIONS OF TECHNOLOGY:
- Screening all 24 chromosomes for numeric chromosome abnormalities during Preimplantation Genetic Diagnosis - Diagnosing disease states requiring cytogenetic analysis - M..
IB-2390
APPLICATIONS OF TECHNOLOGY:
Using MRI data to develop a database that systematically characterizes skin properties
Developing a skin map for a patient and comparing it to the databas..
Abstract
The present invention provides a bacterium containing a unique plasmid. The plasmid is unique in its ability to replicate in both Gram positive and Gram negative bacteria. In addition, the ..
Abstract
The invention relates to the production of protein 2a that can copy, in vitro, any RNA. The invention provides a method for obtaining a stable RNA polymerase enzyme by expressing protein 2a..
The process of mixing fluids, or fluids and particulates, is critical in biology, chemistry, medicine, and engineering and in numerous applications involving the synthesis of pharmaceuticals, flows th..
New Market Opportunity:
Silver nanoparticles have applications in a wide number of fields across the electronics, physics, chemistry and biomedical fields. The optical absorption and fluorescence cha..
