|
PDGF Releasing Matrices for Angiogenesis and Tissue RegenerationBackground Grafting materials (e.g., autografts, allografts) have been used to repair tissue loss from accidents and diseases. Limited attachment and the risk of pathogen transmission and immune rejection of the materials are however major concerns in grafting procedures. The field of tissue engineering has focused on developing new approaches to develop biological alternatives to harvested tissues and organs to restore, maintain and improve tissue function. Such strategies include the development of scaffolds that are highly porous matrices that enable cell attachment and proliferation and development of 3-dimensional tissue formation. Technology Description Researchers at the University of Michigan have developed three-dimensional porous materials for the delivery of biomolecules such as growth factors. The researchers have achieved a porous matrix that are derived from nano- or micro- spheres for in-vivo release of angiogenic and mitogenic factors. The geometry, growth factor loading capabilities, release profile and biodegradability of these matrices are exciting aspects of this technology. The growth factors loaded in the scaffolds retain their biological activity and these scaffolds have been successful in triggering tissue regeneration and angiogenesis in subcutaneous implantations in animals. Applications • Tissue engineering e.g. tissue regeneration and angiogenesis. Advantages • Controlled and prolonged deliveryof biomolecules. • Biodegradable. • High porosity within structure enablesvascularization. See UM File 3600 Inventor(s): Peter X. Ma, Qiming Jin, Guobao Wei, William Giannobile Type of Offer: Licensing Contact the owner of this technology. [MORE MEDICAL DEVICES TECHNOLOGIES] [MORE DENTAL TECHNOLOGIES] |
 |
© 2007-2009 Online Data Services Ltd. All rights reserved.
IdeaConnection and ThinkSpace are trade-marks of Online Data Services Ltd.
IdeaConnection and ThinkSpace are trade-marks of Online Data Services Ltd.